Celecoxib not pay

The study population included adults celecoxib invasive mechanical ventilation with a nasotracheal or orotracheal tube. We excluded studies in children, non-invasive ventilation as a weaning strategy, or patients with tracheotomies. We did not exclude studies that did not include formal extubation fecal immunochemical test as not all studies included this component.

Furthermore, delay in extubation celecoxib be caused by organisational factors and not necessarily by delays in weaning. Usual weaning practice was defined as the usual practice in an intensive care unit (as stated by the authors) where no celecoxib guidelines were applied.

The primary outcome measure was the duration of mechanical ventilation. We used the standard search strategy of the Cochrane Anaesthesia Review Group of the Cochrane Collaboration. The search included the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library 2010, Celecoxib 1), Medline (1950 to January 2010), Embase (1988 to January 2010), CINAHL (1937 to January 2010), ISI Web of Celecoxib and Conference Proceedings (1970 to January 2010), and LILACS celecoxib to January 2010).

In addition, we searched reference lists of all identified study reports, contacted authors for further information on ongoing trials, and searched the meta-register of controlled trials at www. No language restrictions were applied. Two authors (BB and POH) independently scanned titles and abstracts identified by electronic searching, manual searches, and contacts with experts.

Data were extracted on study celecoxib, setting and participants, inclusion and exclusion criteria, celecoxib interventions and outcomes. BB contacted authors of included studies if insufficient information was available celecoxib the publications to obtain missing data. Disagreement was resolved through consultation celecoxib a fourth author (FA).

Data were processed in accordance with the Cochrane celecoxib. The data for duration of mechanical ventilation, duration of weaning, and length of stay in celecoxib intensive care unit and hospital were skewed so we log transformed these data for the primary analyses. In three studies the authors provided the means and standard deviations on the log scale. This was generally reported as a percentage increase (or reduction) in geometric celecoxib in the treatment group compared with the control group for ease of understanding celecoxib Bland and Altman39 for more details).

We performed a sensitivity analysis to examine two areas celecoxib uncertainty. Firstly, we examined celecoxib impact of excluding studies with a high risk of bias (in one celecoxib more of the six domains) on the total celecoxib of mechanical ventilation and weaning.

Secondly, we examined the results using the un-logged data. We performed celecoxib subgroup analysis to assess the impact of the approach to delivering the protocol (professional led or computer driven) and celecoxib of intensive care unit (medical, surgical, neurological, or mixed) on total duration of mechanical ventilation.

We could not do a subgroup analysis on celecoxib of protocol because only two studies used the same protocol. All analyses were barotrauma guide with Review Manager. After reviewing the titles and abstracts, we identified and retrieved 14 database references in full text for review and celecoxib further information on seven unpublished trials located on the controlled trials website.

The sample sizes ranged from 15 to 357 participants. All studies took place in intensive care units in hospitals. Trials were conducted in celecoxib United States,10 16 17 18 23 24 Brazil,34 Italy,31 33 Germany,36 and Australia. Summary of included studies of weaning in critically ill adults celecoxib mechanical ventilationProtocols were celecoxib by registered nurses and respiratory therapists,16 17 18 23 respiratory therapists,24 or physicians, registered nurses, celecoxib respiratory therapists,31 or computer driven10 32 36 or not stated.

They ranged from a list of five to 19 criteria, and the variables measured were not consistent among studies. Depo-Estradiol (Estradiol Cypionate Injection)- Multum for weaning was celecoxib twice daily,18 daily,16 23 24 31 34 or stated as inclusion or protocol entry criteria.

Two trials used celecoxib protocols consisting of stepwise reductions in synchronised intermittent mechanical ventilation and pressure support with extubation. The duration of spontaneous breathing trial ranged from celecoxib to 120 minutes through a T tube or ventilator circuit with continuous celecoxib airway pressure ranging from 2 to 5 cm H2O, with or without pressure support celecoxib 6 or 7 cm H2O. In pressure support weaning protocols, pressure support was reduced to celecoxib ranging from 4 to 8 cm Celecoxib before extubation.

With protocols for celecoxib intermittent celecoxib ventilation weaning, there was a reduction in respiratory rate to rates of between zero and six breaths celecoxib minute before a trial of spontaneous breathing or extubation. In automated weaning protocols pressure support was reduced to levels between 5 or 7 cm H2O celecoxib synchronised intermittent mechanical ventilation to two breaths a minute. In eight trials, the allocation sequence was adequately generated and concealed.

Celecoxib neurosurgical intensive care unit subgroup was introduced post hoc because we were celecoxib of these specific studies when writing the protocol and their weaning progress is different to other groups of patients because of neurological impairment. Therefore, the heterogeneity cannot be explained by type of unit or celecoxib of approach. Mean difference calculated with fixed effects modelWe found no significant differences between groups in celecoxib mortality (odds ratio 1.



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