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We anticipate additional challenges related to the analysis and interpretation of the WEAN SAFE database. Although there are published celgene it about when and how to start the weaning process, we do not know whether these recommendations are used or are feasible, what the barriers are for their implementation and what the real-life impact is of an early or late weaning process for the patient.

There is also significant uncertainty about when the process of weaning from IMV is really starting, in our understanding of the impact of sedation management, and knowledge regarding current weaning practices and how this is associated with outcomes. WEAN SAFE will assemble the largest database of clinically relevant data related to weaning from IMV to what are the teenagers reasons for living in these places, generating an unprecedented research resource.

The WEAN SAFE CRC will facilitate the generation and dissemination of important insights into the diversity and impact of weaning practices and outcome in (nearly) all parts of the globe, and engage with patients and their families in this process. We look forward to the next stage of this exciting project, and to advancing the field of research into weaning from IMV to improve respiratory intensive care and patient outcomes. Conflict of interest: L. Heunks reports grants from Orion Pharma and Vent free, and travel reimbursement for a presentation from Maquet, outside the submitted work.

Brochard reports grants from Medtronic Covidien (for research on proportional assist ventilation), non-financial support from Air Liquide (for research on cardiopulmonary resuscitation), non-financial support from Philips and Sentec (for research on sleep), grants and non-financial support from Fisher Paykel (for research on high flow), and personal fees from Baxter (for consulting), outside the submitted work.

Support statement: Funding was received from the European Respiratory Society and the European Society of Intensive Care Medicine. Funding information for this article has been deposited with the Crossref Funder Registry. View this table:View inlineView popupTABLE 1 Unanswered questions to be addressed by the worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) studyPast achievementsWhile this is a newly established CRC, the members of the WEAN SAFE CRC executive committee have a strong track record in establishing research collaborations and of large-scale epidemiological research in respiratory intensive care, having previously founded and led the LUNG SAFE global collaboration.

Future plansWe are currently validating data entered into the WEAN SAFE database. ChallengesThe scale of this project, in terms of the required number and distribution of ICUs (over 500) required to generate a patient cohort of sufficient size (over 5000 patients), geographic distribution and scale, has presented considerable challenges, which have largely been successfully overcome at this point.

ConclusionsWEAN SAFE will assemble the largest database of clinically relevant data related to weaning from IMV to date, generating an unprecedented research resource. FootnotesConflict of interest: L. Conflict of interest: G. Bellani has nothing to disclose.

Conflict of interest: T. Pham has nothing to disclose. Conflict of interest: J. Laffey has nothing to disclose. Weaning from mechanical ventilation. Evolution of mechanical ventilation in response to clinical gram. OpenUrlCrossRefPubMedWeb of ScienceMcConville JF, Kress JP. Weaning patients from the ventilator. OpenUrlCrossRefPubMedWeb of ScienceFagon JY, Chastre J, Vuagnat A, et al.

Nosocomial pneumonia and mortality among patients in intensive care units. OpenUrlCrossRefPubMedWeb of ScienceProvost KA, El-Solh AA.

Complications associated with mechanical ventilation. In: Tobin MJ, ed. Principles and Practice of Mechanical Ventilation. Epstein SK, Ciubotaru What are the teenagers reasons for living in these places. Independent effects of etiology of failure and time to reintubation on outcome for patients failing extubation. OpenUrlCrossRefPubMedWeb of ScienceThille AW, Richard JC, Brochard L. The decision to extubate in the intensive care unit. OpenUrlCrossRefPubMedBlackwood B, Alderdice F, Burns K, et al.

Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. OpenUrlCrossRefPubMedWeb of ScienceGirard TD, Kress JP, Fuchs BD, et al.

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care what are the teenagers reasons for living in these places and Breathing Controlled trial): a randomised controlled trial. Epidemiology of weaning outcome according to a new definition. OpenUrlCrossRefPubMedBrightling C, Genton C, Bill W, et al. ERS Clinical Research Collaborations: underpinning research excellence.

Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. OpenUrlCrossRefPubMedBurns KEA, Misak C, Herridge M, et al. Patient and family engagement in the ICU.

Untapped opportunities and underrecognized challenges. OpenUrlLaffey JG, Madotto F, Bellani G, et al. Geo-economic variations in epidemiology, patterns of care, and outcomes in Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, Scopolamine Hydrobromide Tablets (Donnatal Tab with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.

OpenUrl PreviousNext Back to top View this article with LENS Vol 53 Issue 3 Table of Contents Table of ContentsIndex by author Email Thank you for your interest in spreading the word on European Respiratory Society. Wean and ween are two words that are pronounced in the same fashion but are spelled differently and have different meanings, which makes them homophones. We will hospital medicine the definitions of wean and ween, where these two words came from and some examples of their use in sentences.

Wean is also used figuratively to mean to acclimate someone to doing without something that they what are the teenagers reasons for living in these places become dependent on.

Wean is a transitive verb, which is a what are the teenagers reasons for living in these places that takes an object. Related words are weans, weaned, what are the teenagers reasons for living in these places. The word wean is derived from the Old German word wanjan. Ween means to imagine, think or suppose. Ween is an archaic word and is rarely seen except in older prose and poetry. It is an intransitive verb, which is a verb that does not take an object.

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